Our work on identifying new players in B cell activation by proximity proteomics is out!
We used APEX2-mediated proximity biotinylation proteomics method to map the protein dynamics at the vicinity of the BCR during the first 15 minutes of antigenic activation. From the newly identified proteins, we demonstrated a role of SUMOylation in BCR signaling, identifying SUMO as a novel posttranslational modification regulating early B cell activation.
Check it out in here.