The lab swapped pipettes for chopsticks and climbing harnesses this summer. We kicked off with a sushi lunch before heading to FlowPark for an afternoon in the trees. Turns out that climbing trees is significantly harder than science, which, considering what we do for a living, says a lot.
Pinja was awarded a 1-year (60.000€) project grant from Sakari Alhopuro Foundation! Congratulations!
The lab welcomed their new support dog named Scar. While most of the lab memebers will be workig on the lab, Scar will be in the office offering his expertises and cuddles to everyone in need. A must need for every lab 😃
New preprint freshly coming through! Check it out here if you are interested in B cells, extracellular vesicles virus or omics.
Oliver joins the lab as our new PhD student. He will focus on drugs repurposing and characterization of B cell populations on autoimmune disease settings. Excited to have you!
This year’s pikkujoulu brought the lab together for an escape room followed by an excellent dinner. The puzzles were tricky, the teamwork was (eventually) solid, and the evening ended exactly as it should around a great table with even better company. A well-earned break, and a night to remember for Mattila lab.
Honored to be part of Yuseff on their new paper uncovering B cell mechanotransduction at the immune synapse!
The recent work reveals how B cells sensing antigens on stiff substrates trigger a sophisticated mechanotransduction pathway. This process shuttles the microtubule acetylase ATAT1 from the nucleus to the cytoplasm, boosting alpha-tubulin acetylation. This specific acetylation frees GEF-H1 at the immune synapse, driving the formation of actin foci that generate the mechanical forces required for antigen extraction
Congratulations to all the brilliant authors involved in this work! 🥂✨
You can check out the full paper here!
The Mattila lab went out into the park this Summer in a highly competitive game of Mölkky, a traditional Finnish garden game. As always there are no winners or losers, just a lot of fun and laughter.
