Lymphocyte Activation Lab


Find selected publications below. List of all publications on Pubmed (link).


Hämälistö S, Del Valle Batalla F, Yuseff MI, Mattila PK. J Cell Biol. (2024) Endolysosomal vesicles at the center of B cell activation. Feb 2;223(3):e202307047. doi:10.1083/jcb.202307047.

Runsala M, Kuokkanen E, Uski E, Šuštar V, Balci MÖ, Rajala J, Paavola V, Mattila PK. Cells. (2023) The Small GTPase Rab7 Regulates Antigen Processing in B Cells in a Possible Interplay with Autophagy Machinery. Nov 2;12(21):2566. doi: 10.3390/cells12212566.

Aleksi IsomursuJonna AlankoSara Hernández-PérezKarla SaukkonenMarkku SaariPieta K. MattilaJohanna Ivaska (2023) Dynamic Micropatterning Reveals Substrate-Dependent Differences in the Geometric Control of Cell Polarization and Migration  Small Methods. 2300719

Awoniyi LO, Cunha DM, Sarapulov AV, Hernández-Pérez S, Runsala M, Tejeda-González B, Šuštar V, Balci , Petrov P, Mattila PK (2023) B cell receptor-induced protein dynamics and the emerging role of SUMOylation revealed by proximity proteomics  Journal of Cell Science. Volume 136, Issue 15

Diogo M Cunha, Hernández-Pérez S, Mattila PK (2023) Isolation of the B Cell Immune Synapse for Proteomic Analysis. Methods in Molecular Biology. 2654:393-408

Amna Music*, Blanca Tejeda-González*, Diogo M Cunha, Gabriele Fischer von Mollard, Sara Hernández-Pérez, Pieta K Mattila (2022) The SNARE protein Vti1b is recruited to the sites of BCR activation but is redundant for antigen internalisation, processing and presentation Frontiers in Cell and Developmental Biology 10:987148

Petrov P, Awoniyi LO, Šuštar V, Balci MÖ & Mattila PK (2022) AutoCoEv—A High-Throughput In Silico Pipeline for Predicting Inter-Protein Coevolution International Journal of Molecular Sciences 23(6), 3351

Sara Hernández-Pérez & Pieta K. Mattila (2022) A specific hybridisation internalisation probe (SHIP) enables precise live-cell and super-resolution imaging of internalized cargo Scientific Reports volume 12, Article number: 620

Sara Hernández-Pérez, Marika Runsala, Vid Šuštar, Pieta K. Mattila (2021) Analysis of Intracellular Vesicles in B Lymphocytes: Antigen Traffic in the Spotlight Methods in Molecular Biology 2304:173-191.

Awoniyi LO, Runsala M, Šuštar V, Hernández-Pérez S, Sarapulov AV, Petrov PB & Mattila PK (preprint) Novel players and large-scale protein dynamics of BCR activation revealed by APEX2 proximity labelling of lipid rafts bioRxiv 2020.09.29.318766

von Chamier L, Laine RF, Jukkala J, Spahn C, Krentzel D, Nehme E, Lerche M, Hernández-Pérez S, Mattila PK, Karinou E, Holden S, Solak AC, Krull A, Buchholz T-O, Jones ML, Royer LA, Leterrier C, Shechtman Y, Jug F, Heilemann M, Jacquemet G & Henriques R (2021) Democratising deep learning for microscopy with ZeroCostDL4Mic Nature Communications. 12, Article number: 2276

Sarapulov AV, Petrov P, Hernández-Pérez S, Šuštar V, Kuokkanen E, Cords L, Samuel RVM, Vainio M, Fritzsche M, Carrasco YR, Mattila PK (2020) Missing-In-Metastasis / Metastasis Suppressor 1 modulates B cell receptor signaling, B cell metabolic potential and T cell-independent immune responses. Frontiers in Immunology. doi: 10.3389/fimmu.2020.00599

Hernández-Pérez S*Vainio M*Kuokkanen ESustar VPetrov PFórsten SPaavola VRajala J, Awoniyi LO, Sarapulov AV, Vihinen H, JokitaloE,Bruckbauer A, Mattila PK (2020) B cells rapidly target antigen and surface-derived MHCII into peripheral degradative compartments. Journal of Cell Science

* the authors contributed equally to the study.

Petrov PSarapulov AV, Eory L, Scielzo C, Scarfo L, Smith J, Burt DW and Mattila PK(2019) Computational analysis of the evolutionarily conserved Missing In Metastasis/Metastasis Suppressor 1 gene predicts novel interactions, regulatory regions and transcriptional control Scientific Reports. 9:4155 | 

Šuštar V, Vainio M, Mattila PK(2018) Visualization and quantitative analysis of the actin cytoskeleton upon B cell activation. Methods in Molecular Biology. 1707:243-257. 

Burbage M, Keppler SJ, Montaner B, Mattila PK* and Batista FD. (2017) The Small Rho GTPase TC10 Modulates B Cell Immune Responses. Journal of Immunol.199:1682-1695 (IF 5.2; cit -) *corresponding author

Mattila PK, Batista FD, Treanor B. (2016) Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling. Journal of Cell Biology212:267-80.

Gasparrini F, Feest C, Bruckbauer A, Mattila PK, Müller J, Nitschke L, Bray D, Batista FD. (2016) Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling. EMBO Journal 35:258-80.

Kuokkanen E, Šuštar V, Mattila PK (2015) Molecular control of B cell activation and immunological synapse formation. Traffic. 16:311-26.

Mattila PK, Feest C, Depoil D, Treanor B, Montaner B, Otipoby KL, Carter R, Justement LB, Bruckbauer A, Batista FD. (2013) The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling. Immunity. 38:461-74.
– Recommended in F1000 Prime 

Saarikangas J*, Mattila PK*, Varjosalo M, Bovellan M, Hakanen J, Calzada-Wack J, Tost M, Jennen L, Rathkolb B, Hans W, Horsch M, Hyvönen ME, Perälä N, Fuchs H, Gailus-Durner V, Esposito I, Wolf E, de Angelis MH, Frilander MJ, Savilahti H, Sariola H, Sainio K, Lehtonen S, Taipale J, Salminen M, Lappalainen P. (2011) Missing-in-metastasis (MIM/MTSS1) Promotes Actin Assembly at Intercellular Junctions and Is Required for Kidney Epithelia IntegrityJournal of Cell Science; 124:1245-55. *equal contribution

Mattila PK, Lappalainen P. (2008) Filopodia: molecular architecture and cellular functions. Nature Reviews Molecular Cell Biology; 9:446-54.

Mattila PK, Pykäläinen A, Saarikangas J, Paavilainen VO, Vihinen H, Jokitalo E, Lappalainen P. (2007) Missing-In-Metastasis (MIM) and IRSp53 deform PI(4,5)P2-rich membranes in an inverse BAR-like mechanism. Journal of Cell Biology; 176:953-64.
– Recommended in F1000 Prime 
– Highlight article: Williams R. (2007) Bending membrane to form filopodia. Journal of Cell Biology; 176:890a. 
– Highlight article: Cory GOC, Cullen PJ. (2007) Membrane Curvature: The Power of Bananas, Zeppelins and Boomerangs. Dispatches. Current Biology; 17: R455-R457.