Since last March, we have welcomed a new lab intern and a MSc student that will perform her thesis with us.
Anni Virtanen, currently undergoing her BSc in Biochemistry in UTU, has been a multitasking force around the lab helping in several projects and always eager to learn more and more.
Maria Tarczewska, currently performing her MSc studies in BIMA program, has been more focused on the extracellular vesicles projects and is very keen on expansion microscopy.
Welcome aboard and all the best!
Our Erasmus intern Özge Balci got accepted in the MSc programme of Biomedical Imaging (joint programme between University of Turku and Åbo Akademi University) with full scholarship! Moreover, she was also granted a Finnish Scolarship for the next 2 years as the top merit applicant of the programme.
Well done and keep up the good work!
We are pleased to announce that our latest paper, titled “AutoCoEv-A High-Throughput In Silico Pipeline for Predicting Inter-Protein Coevolution” has been accepted for publication in the International Journal of Molecular Sciences! The article can be found through here. Accompanying scripts can be found at GitHub.
“AutoCoEv – A High-Throughput In Silico Pipeline for Predicting Inter-Protein Coevolution” offers a a user-friendly, open source, computational pipeline, that enables the search of coevolution within a large number of proteins from a predetemrined dataset. By driving 15 individual programs, culminating in CAPS2 as the software for detecting coevolution, AutoCoEv achieves a seamless automation and parallelization of the workflow. Importantly, a patch to the CAPS2 source code is provided to strengthen its statistical output, allowing for multiple comparison corrections and an enhanced analysis of the results.
Thanks to all involved!
Congratulation to our very own first PhD graduate from Mattila lab, Alexey Sarapulov who successfully defended his PhD thesis entitled “B cell-mediated immunity and signal regulation” on March 11th. We extend our warm gratitude to Professor Lars Nitschke, his opponent from Friedrich-Alexander-Universität Erlangen-Nürnberg, for accepting the invitation and for such an amazing scientific discussion.
The thesis can be found here.
Mattila’s lab members wish all the best on Alexey’s new endeavours!
We are thrilled to announce that our article titled “A specific hybridisation internalisation probe (SHIP) enables precise live-cell and super-resolution imaging of internalized cargo”, has been published in Scientific Reports. The article can be found here.
The specific hybridization internalisation probe (SHIP) assay, developed for flow cytometry studies, employs a ssDNA fluorescence internalisation probe and a complementary ssDNA quenching probe to unambiguously detect the internalized receptors/cargo. We take advantage of the SHIP assay to study the trafficking of receptor/ligand complexes using B lymphocytes and B cell receptor-mediated antigen internalization as a model system.
Our article has been included in the “Editor’s choice: super-resolution microscopy” which highlights the versatility and significance of this model system.
Congratulations to all involved!
, 12 Jan 2022, 12(1):620, doi
Excited to host a special seminar by Dr María Isabel Yuseff on Thursday (03 Feb) on “Coupling Cytoskeleton Dynamics to Polarized lysosome Trafficking: Impact on B cell Responses”
Congratulations Saara and Amna for the awesome work at securing personal funding!
Thank you, Finnish Cultural Foundation and the University of Turku Graduate School!
Happy to host Dr María Isabel Yuseff and MSc Felipe Del Valle on a research visit!! Welcome to snowy Turku, Isabel and Felipe!
Check out our latest manuscript on utilization of SHIP method to specifically visualize internalized receptor without the background from the plasma membrane-bound pool!
Also check out the awesome thread by Sara on Twitter
During the fall 2021, our lab grew with a postdoc Saara Hämälistö, PhD student Blanca Tejeda and an Erasmus intern Özge Balcı! Super-exited! A generation change is on the way 😃
